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pentobarbital will lower the level or influence of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can decrease panobinostat ranges by ~70% and lead to treatme